中文摘要：荧光碳纳米粒子以其优异的荧光性能和简单的合成路径近年来备受关注。用于合成荧光纳米碳粒子的碳源很多，但使用病毒粒子的情况很少。本文报道了用M13噬菌体粒子作为碳源，通过简单的一步微波加热合成噬菌体纳米粒子。M13噬菌体是一种纳米大小的丝状病毒粒子，其大量外壳蛋白包裹着单链DNA基因组。这些富含氨基酸的粒子为荧光纳米粒子的合成提供了丰富的碳源。M13噬菌体制备的纳米粒子具有良好的水溶性，并表现出明亮的蓝色荧光；其对Fe(iii)离子的选择性和灵敏度表现出线性相关的猝灭效应。本研究突出了病毒粒子作为荧光碳纳米粒子合成来源和传感应用的潜在价值。
外文摘要：Fluorescent carbon nanoparticles have been gaining more attention in recent years for their excellent fluorescence properties and simple synthesis routes. Different carbon sources have been reported for fluorescent carbon nanoparticle synthesis but the use of virus particles as a carbon source is scarce. Herein, we report the utilization of M13 bacteriophage particles as the carbon source to synthesize phage-based nanoparticles through facile, one-step microwave heating. M13 bacteriophage is a nanosized filamentous virus particle with a single-stranded DNA genome encapsulated by a large number of coat proteins. These amino acid rich building blocks provide a substantial amount of carbon source for the synthesis of fluorescent nanoparticles. The resulting nanoparticles from M13 bacteriophage showed good water solubility and exhibited bright blue luminescence. The selectivity and sensitivity of the phage-based nanoparticles towards Fe(iii) ions showed a quenching effect with a linear correlation and a detection limit of 8.0 mu M. This process highlights the potential application of virus particles as a source for the synthesis of fluorescent carbon nanoparticles and the sensing application.
作者：Lai, JY；Inoue, N；Oo, CW；Kawasaki, H；Lim, TS
作者单位：Univ Sains Malaysia；Kansai Univ
期刊名称：RSC ADVANCES
期刊影响因子：3.119
出版年份：2021
出版刊次：3
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