中文摘要：甲型流感病毒的进化能力，及抗菌素耐药性的增加，可能引起流感大流行，造成巨大的发病率和死亡率。1918年流感大流行的大部分死亡可能是由包括金黄色葡萄球菌在内的肺炎细菌合并感染引起的。金黄色葡萄球菌对许多抗生素都具有耐药性。由于缺乏新的抗生素，则需要开发替代抗菌素，如噬菌体。潜在的噬菌体疗法(BT)给药方式包括吸入和静脉注射。BT最近已成功应用于肺部感染危重病例。噬菌体细胞溶解酶是一种能够水解细菌细胞壁并具有杀菌作用的酶，对动物肺炎模型有效。对于BT能否改善流感和金黄色葡萄球菌合并感染，还需要通过临床试验来确定。
外文摘要：The ability of influenza A virus to evolve, coupled with increasing antimicrobial resistance, could trigger an influenza pandemic with great morbidity and mortality. Much of the 1918 influenza pandemic mortality was likely due to bacterial coinfection, including Staphylococcus aureus pneumonia. S. aureus resists many antibiotics. The lack of new antibiotics suggests alternative antimicrobials, such as bacteriophages, are needed. Potential delivery routes for bacteriophage therapy (BT) include inhalation and intravenous injection. BT has recently been used successfully in compassionate access pulmonary infection cases. Phage lysins, enzymes that hydrolyze bacterial cell walls and which are bactericidal, are efficacious in animal pneumonia models. Clinical trials will be needed to determine whether BT can ameliorate disease in influenza and S. aureus coinfection.
外文关键词：bacteriophages；drug resistance；influenza；microbial；pneumonia；secondary infection；Staphylococcus aureus
作者：Speck, PG；Warner, MS；Bihari, S；Bersten, AD；Mitchell, JG；Tucci, J；Gordon, DL
作者单位：Flinders Univ South Australia；Queen Elizabeth Hosp；SA Pathol；Univ Adelaide,；Flinders Med Ctr；La Trobe Univ
期刊名称：FUTURE MICROBIOLOGY
期刊影响因子：2.907
出版年份：2021
出版刊次：3
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