中文摘要：细菌生物膜可以通过提供对抗生素和传统消毒剂的耐药性来增强细菌生存能力。生物膜的存在严重威胁着人类健康，造成不可估量的损失。因此，亟需处理细菌生物膜的新策略。噬菌体因其对细菌有活性，不会对人类构成威胁而独具优势，是治疗细菌性疾病的安全替代药物。它们能有效地清除细菌生物膜，在医疗、食品工业和污染控制等方面有很大的潜力。噬菌体与生物膜之间存在着复杂的相互作用机制：生物膜可以防止噬菌体入侵，而噬菌体可以杀死细菌，控制生物膜或影响生物膜形成。目前，通过噬菌体防治生物膜的措施多种多样，包括联合用药和噬菌体混合疗法。本文主要综述了细菌生物膜的功能和形成过程，总结了噬菌体和生物膜的不同作用机制，简要阐述了噬菌体在控制细菌生物膜中的作用，促进噬菌体在维护人体健康和保护自然环境中的应用。
外文摘要：Bacterial biofilms can enhance bacteria's viability by providing resistance against antibiotics and conventional disinfectants. The existence of biofilm is a serious threat to human health, causing incalculable loss. Therefore, new strategies to deal with bacterial biofilms are needed. Bacteriophages are unique due to their activity on bacteria and do not pose a threat to humans. Consequently, they are considered safe alternatives to drugs for the treatment of bacterial diseases. They can effectively obliterate bacterial biofilms and have great potential in medical treatment, the food industry, and pollution control. There are intricate mechanisms of interaction between phages and biofilms. Biofilms may prevent the invasion of phages, and phages can kill bacteria for biofilm control purposes or influence the formation of biofilms. At present, there are various measures for the prevention and control of biofilms through phages, including the combined use of drugs and the application of phage cocktails. This article mainly reviews the function and formation process of bacterial biofilms, summarizes the different mechanisms between phages and biofilms, briefly explains the phage usage for the control of bacterial biofilms, and promotes phage application maintenance human health and the protection of the natural environment.
外文关键词：biofilm；phage；drug-resistant bacteria；antibiotic substitute；bacterial biofilm control
作者：Tian, FJ；Li, J；Nazir, A；Tong, YG
作者单位：Beijing Univ Chem Technol
期刊名称：INFECTION AND DRUG RESISTANCE
期刊影响因子：2.984
出版年份：2021
出版刊次：14
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