中文摘要：本报告评估了一种降低由单纯疱疹病毒感染引起的眼部感染严重程度的饮食处理方法。由于感染引起T细胞协同炎症反应，这种病毒会导致角膜的慢性损伤。如果具有调节活性的细胞在促炎T细胞和非淋巴类炎症细胞中占主导地位，病变的严重程度会受到限制。本研究证明了在饮用水中加入短链脂肪酸(SCFA)盐丙酸钠(SP)可以达到这一效果。服用SP补充剂的动物，眼部病变明显少于未服用补充剂的动物。角膜和淋巴器官中CD4 Th1和Th17 T细胞、中性粒细胞和巨噬细胞较对照组少，但调节性T细胞(Treg)出现频率较高。在体外培养中加入SP诱导CD4 T细胞亚群降低了Th1和Th17反应的幅度，但扩大了Treg的诱导。饮食处理是限制病毒免疫炎性病变严重程度的有效方法，是一种值得探索的、减少疱疹病变影响人类的手段。
重要性：疱疹性病变是一个严重的问题，很难用治疗方法控制。本研究表明，小鼠模型中的疱疹病变的严重程度可以通过改变饮食，包括增加SCFA水平来降低，SCFA的作用是抑制炎症T细胞的参与。研究建议改变饮食，包括更高水平的短链脂肪酸可能是减少复发性疱疹病变对人类影响的方法。
外文摘要：This report evaluates a dietary manipulation approach to suppress the severity of ocular infections caused by herpes simplex virus infection. The virus causes chronic damage to the cornea that results from a T-cell-orchestrated inflammatory reaction to the infection. Lesion severity can be limited if cells with regulatory activity predominate over proinflammatory T cells and nonlymphoid inflammatory cells. In this report, we show that this outcome can be achieved by including the short-chain fatty acid (SCFA) salt sodium propionate (SP) in the drinking water. Animals given the SP supplement developed significantly fewer ocular lesions than those receiving no supplement. Corneas and lymphoid organs contained fewer CD4 Th1 and Th17 T cells, neutrophils, and macrophages than those of controls, but a higher frequency of regulatory T cells (Treg) was present. The inclusion of SP in cultures to induce CD4 T cell subsets in vitro reduced the magnitude of Th1 and Th17 responses but expanded Treg induction. Dietary manipulation was an effective approach to limit the severity of viral immuno-inflammatory lesions and may be worth exploring as a means to reduce the impact of herpetic lesions in humans.
   IMPORTANCE Herpetic lesions are a significant problem, and they are difficult to control with therapeutics. Our studies show that the severity of herpetic lesions in a mouse model can be diminished by changing the diet to include increased levels of SCFA, which act to inhibit the involvement of inflammatory T cells. We suggest that changing the diet to include higher levels of SCFA might be a useful approach to reducing the impact of recurrent herpetic lesions in humans.
外文关键词：HSV-1；sodium propionate；proinflammatory；anti-inflammatory immune cells
作者：Sumbria, D；Berber, E；Rouse, BT
作者单位：Univ Tennessee；Erciyes Univ
期刊名称：JOURNAL OF VIROLOGY
期刊影响因子：4.501
出版年份：2021
出版刊次：4
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