中文摘要：乳腺炎是乳业中最重要的疾病。抗生素是治疗该病的首选药物。然而，抗生素残留、抗生素耐药性问题，以及抗生素滥用对公共卫生的影响，为全球奶业不受控制的抗生素治疗带来了诸多限制。研究人员已研究出取代抗生素治疗乳腺炎的新方法。在纳米技术、干细胞分析、分子生物学工具和基因组学的革命性发展的支持下，开发防控乳腺炎的新方法成为可能。本综述讨论了控制乳腺炎的最新概念，如培育乳腺炎抗性奶牛，开发新型诊断和治疗工具，应用通信技术作为教育和流行病学工具，使用现代乳腺炎疫苗，奶牛干燥协议，乳头消毒，棚舍及营养。包括纳米技术、干细胞技术、光动力和激光治疗的应用，或使用传统草药、营养品、抗菌肽、细菌素、抗体治疗、噬菌体、噬菌体细胞裂解酶和益生菌替代抗生素。
外文摘要：Mastitis is the most important disease in the dairy industry. Antibiotics are considered to be the first choice in the treatment of the disease. However, the problem of antibiotic residue and antimicrobial resistance, in addition to the impact of antibiotic abuse on public health, leads to many restrictions on uncontrolled antibiotic therapy in the dairy sector worldwide. Researchers have investigated novel therapeutic approaches to replace the use of antibiotics in mastitis control. These efforts, supported by the revolutionary development of nanotechnology, stem cell assays, molecular biological tools, and genomics, enabled the development of new approaches for mastitis-treatment and control. The present review discusses recent concepts to control mastitis such as breeding of mastitis-resistant dairy cows, the development of novel diagnostic and therapeutic tools, the application of communication technology as an educational and epidemiological tool, application of modern mastitis vaccines, cow drying protocols, teat disinfection, housing, and nutrition. These include the application of nanotechnology, stem cell technology, photodynamic and laser therapy or the use of traditional herbal medical plants, nutraceuticals, antibacterial peptides, bacteriocins, antibodies therapy, bacteriophages, phage lysins, and probiotics as alternatives to antibiotics.
外文关键词：Bacteriocins；Bacteriophage therapy；Dairy；Disinfectants；Education；Mastitis；Microbiota；MRSA；Nanotechnology；Nutraceuticals；Probiotics；Resistant breeds； Staphylococcus aureus；Stem cells
作者：El-Sayed, A；Kamel, M
作者单位：Cairo Univ
期刊名称：TROPICAL ANIMAL HEALTH AND PRODUCTION
期刊影响因子：1.333
出版年份：2021
出版刊次：2
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