中文摘要：由于医疗保健的进步，大量的医疗设备被用于治疗人类疾病。反之，由于生物膜对抗菌素的耐受性，生物膜相关感染已成为一个日益严重的威胁，并因全球抗菌素耐药性的发展更加凸显。因此，仅通过抗菌素成功治疗生物膜感染不现实。本文总结了一些经典的替代抗菌素治疗生物膜感染的方法。虽不够详尽，但提供了一个临床上替代抗菌药物治疗生物膜疾病的可能，更注重接近临床实践的应用。开发新型抗菌膜疗法存在许多突出的困难。筛选有效的抗菌膜化合物需要与所有临床场景相关的模型。尽管过去十年对体外抗生物膜方法的研究取得了显著进展，但体内研究仍然缺乏。此外，生物膜生物学很复杂，想要开发一种单一“魔弹”型化合物非常困难。生物膜的多面性需要进行多靶点或组合治疗。
外文摘要：Introduction: As a result of progress in medical care, a huge number of medical devices are used in the treatment of human diseases. In turn, biofilm-related infection has become a growing threat due to the tolerance of biofilms to antimicrobials, a problem magnified by the development of antimicrobial resistance worldwide. As a result, successful treatment of biofilm-disease using only antimicrobials is problematic.
   Areas covered: We summarize some alternative approaches to classic antimicrobials for the treatment of biofilm disease. This review is not intended to be exhaustive but to give a clinical picture of alternatives to antimicrobial agents to manage biofilm disease. We highlight those strategies that may be closer to application in clinical practice.
   Expert opinion: There are a number of outstanding challenges in the development of novel antibiofilm therapies. Screening for effective antibiofilm compounds requires models relevant to all clinical scenarios. Although in vitro research of anti-biofilm strategies has progressed significantly over the past decade, there is a lack of in vivo research. In addition, the complexity of biofilm biology makes it difficult to develop a compound that is likely to provide the single 'magic bullet'. The multifaceted nature of biofilms imposes the need for multi-targeted or combinatorial therapies.
 
外文关键词：Biofilm disease；recalcitrance；antibiofilm；coatings；biofilm dispersal；quorum quenching；phages；photodynamic therapy；persister；bioelectric effect
作者：Del Pozo, JL
作者单位：Clin Univ Navarra
期刊名称：EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
期刊影响因子：3.767
出版年份：2021
出版刊次：
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