中文摘要：受体酪氨酸激酶(RTKs)调节细胞生长、生存、运动和代谢等关键的生理过程。RTK和相关下游信号通路的异常激活与癌症的发病有关。噬菌体展示可以快速选择膜受体的肽配体。这些肽可以靶向体内外的肿瘤细胞，提供了一种治疗癌症的新方法。此外，与抗体相比，它们更方便、更便宜、无免疫原性。本文综述了噬菌体展示技术在酪氨酸激酶膜受体肽配体开发中的最新进展，并讨论了它们在肿瘤靶向治疗中的潜在应用。
外文摘要：Receptor tyrosine kinases (RTKs) regulate critical physiological processes, such as cell growth, survival, motility, and metabolism. Abnormal activation of RTKs and relative downstream signaling is implicated in cancer pathogenesis. Phage display allows the rapid selection of peptide ligands of membrane receptors. These peptides can target in vitro and in vivo tumor cells and represent a novel therapeutic approach for cancer therapy. Further, they are more convenient compared to antibodies, being less expensive and non-immunogenic. In this review, we describe the state-of-the-art of phage display for development of peptide ligands of tyrosine kinase membrane receptors and discuss their potential applications for tumor-targeted therapy.
外文关键词：phage display；peptide ligands；tyrosine kinase receptors；tumor-targeting
作者：Aloisio, A；Nistico, N；Mimmi, S；Maisano, D；Vecchio, E；Fiume, G；Iaccino, E；Quinto, I
作者单位：Magna Graecia Univ Catanzaro
期刊名称：VIRUSES-BASEL
期刊影响因子：3.816
出版年份：2021
出版刊次：4
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