中文摘要：由于人类冠状病毒通过呼吸道飞沫传播，对科学界来说，设计自消毒表面以抑制SARS-CoV-2的传播极具挑战性。二氧化钛(TiO2)纳米复合抗菌涂层是一种光照条件下消除普通表面病原体(病毒、细菌、真菌)的理想方法。本综述重点介绍了近年来TiO2纳米复合抗菌涂层的光催化表面消毒牙科和骨科植入物的效果。将无机金属(如铜(Cu)、银(Ag)、锰(Mn)等)、非金属(如氟(F)、钙(Ca)、磷(P))和二维材料(如MXenes、MOF、石墨烯)掺入TiO2中，调节电荷转移机制、表面孔隙率、结晶度和微生物消毒效率。本文评估了TiO2涂层对大肠杆菌、耐甲氧西林金黄色葡萄球菌、铜绿假单胞菌、枯草芽孢杆菌、嗜肺军团菌、金黄色葡萄球菌、变异链球菌、T2噬菌体、H1N1病毒、HCoVNL63病毒、水疱性口炎病毒、牛冠状病毒等最重要的致病微生物的抗菌活性。用硅烷功能化剂和聚合物覆于钛(Ti)金属植入物表面，引入超疏水特性，避免微生物粘附。TiO2纳米复合涂层在牙科和骨科金属植入物中显示出卓越的生物耐蚀性、耐久性、生物相容性、骨形成能力和长效抗菌能力。此外，本文还简要讨论了抗菌纳米复合涂层的商业发展趋势、技术经济、面临的挑战和发展前景。
外文摘要：Engineering of self-disinfecting surfaces to constrain the spread of SARS-CoV-2 is a challenging task for the scientific community because the human coronavirus spreads through respiratory droplets. Titania (TiO2) nanocomposite antimicrobial coatings is one of the ideal remedies to disinfect pathogens (virus, bacteria, fungi) from common surfaces under light illumination. The photocatalytic disinfection efficiency of recent TiO2 nanocomposite antimicrobial coatings for surfaces, dental and orthopaedic implants are emphasized in this review. Mostly, inorganic metals (e.g. copper (Cu), silver (Ag), manganese (Mn), etc), non-metals (e.g. fluorine (F), calcium (Ca), phosphorus (P)) and two-dimensional materials (e.g. MXenes, MOF, graphdiyne) were incorporated with TiO2 to regulate the charge transfer mechanism, surface porosity, crystallinity, and the microbial disinfection efficiency. The antimicrobial activity of TiO2 coatings was evaluated against the most crucial pathogenic microbes such as Escherichia coli, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Legionella pneumophila, Staphylococcus aureus, Streptococcus mutans, T2 bacteriophage, H1N1, HCoVNL63, vesicular stomatitis virus, bovine coronavirus. Silane functionalizing agents and polymers were used to coat the titanium (Ti) metal implants to introduce superhydrophobic features to avoid microbial adhesion. TiO2 nanocomposite coatings in dental and orthopaedic metal implants disclosed exceptional bio-corrosion resistance, durability, biocompatibility, bone-formation capability, and long-term antimicrobial efficiency. Moreover, the commercial trend, techno-economics, challenges, and prospects of antimicrobial nanocomposite coatings are also discussed briefly.
外文关键词：Photocatalyst; SARS-CoV-2; MRSA; E; coli; Biofilm; ROS
作者：Kumaravel, V；Nair, KM；Mathew, S；Bartlett, J；Kennedy, JE；Manning, HG；Whelan, BJ；Leyland, NS；Pillai, SC
作者单位：Inst Technol Sligo；Kastus Technol
期刊名称：CHEMICAL ENGINEERING JOURNAL
期刊影响因子：10.652
出版年份：2021
出版刊次：416
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