中文摘要：对临床药物耐药性不可避免地蔓延需要维持一个完整的抗生素候选渠道。生物体在进化史上挣扎着生存和竞争中，已经发展出一种能力，即制造出一系列以细胞膜为目标的各种各样的天然产物。少量已经用于临床，但大多数尚未开发。用于革兰氏阳性菌的底物结合抗菌素、噬菌体衍生的细胞裂解酶和用于革兰氏阴性菌的外膜蛋白靶向剂，代表了将大自然的馈赠用于临床的有希望的途径。
外文摘要：The inexorable spread of resistance to clinically used drugs demands that we maintain a full pipeline of antibiotic candidates. As organisms have struggled to survive and compete over evolutionary history, they have developed the capacity to make a remarkably diverse array of natural products that target the cell envelope. A few have been developed for use in the clinic but most have not, and there are still an enormous number of opportunities to investigate. Substrate-binding antibiotics for Gram-positive organisms, phage-derived lysins, and outer membrane protein targeting agents for Gram-negative organisms represent promising avenues where nature's gifts may be repurposed for use in the clinic.
外文关键词：OUTER-MEMBRANE；PEPTIDOGLYCAN PRECURSOR；VANCOMYCIN RESISTANCE；WALL BIOSYNTHESIS；PORE FORMATION；LIPOPOLYSACCHARIDE；IDENTIFICATION；INHIBITION；PROTEINS；COMPLEX
作者：Page, JE；Walker, S
作者单位：Harvard Med Sch
期刊名称：CURRENT OPINION IN MICROBIOLOGY
期刊影响因子：8.288
出版年份：2021
出版刊次：61
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