中文摘要：铜绿假单胞菌是引起医疗相关疾病最常见的病原之一，也是世界卫生组织（WHO）列出的三大优先病原体之一。这种革兰氏阴性病原体尤其难以根除，因为它对许多抗生素表现出很高的内在和后天耐药性。此外，人们越来越注意到针对耐多药(MDR)和广泛耐药(XDR) 铜绿假单胞菌感染的抗生素的缺乏，因此有必要采用替代疗法。噬菌体是一种针对并感染细菌细胞的病毒，它们是对抗MDR感染的有希望的候选药物。本综述旨在强调噬菌体治疗的临床药理学，如药代动力学、制剂和剂量，同时解决几个与噬菌体治疗MDR铜绿假单胞菌感染相关的问题。进一步研究噬菌体的药代动力学和药效学将有助于指导有兴趣的临床医生和噬菌体研究人员在噬菌体治疗MDR铜绿假单胞菌感染方面取得更大的成功。
外文摘要：Pseudomonas aeruginosa is one of the most common causes of healthcare-associated diseases and is among the top three priority pathogens listed by the World Health Organization (WHO). This Gram-negative pathogen is especially difficult to eradicate because it displays high intrinsic and acquired resistance to many antibiotics. In addition, growing concerns regarding the scarcity of antibiotics against multidrug-resistant (MDR) and extensively drug-resistant (XDR) P. aeruginosa infections necessitate alternative therapies. Bacteriophages, or phages, are viruses that target and infect bacterial cells, and they represent a promising candidate for combatting MDR infections. The aim of this review was to highlight the clinical pharmacology considerations of phage therapy, such as pharmacokinetics, formulation, and dosing, while addressing several challenges associated with phage therapeutics for MDR P. aeruginosa infections. Further studies assessing phage pharmacokinetics and pharmacodynamics will help to guide interested clinicians and phage researchers towards greater success with phage therapy for MDR P. aeruginosa infections.
外文关键词：bacteriophages；multidrug resistance (MDR)；Pseudomonas aeruginosa
作者：Holger, D；Kebriaei, R；Morrisette, T；Lev, K；Alexander, J；Rybak, M
作者单位：Wayne State Univ；AdventHlth Cent Florida；Detroit Med Ctr
期刊名称：ANTIBIOTICS-BASEL
期刊影响因子：3.893
出版年份：2021
出版刊次：5
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