中文摘要：包括溃疡性结肠炎（UC）和克罗恩病（CD）在内的炎症性肠病（IBD），受肠道内发现的细菌和真菌的影响。然而，肠道也是大量病毒颗粒的家园，其中大多数是感染原核生物的病毒--噬菌体。目前虽然正在研究用噬菌体专门针对IBD相关致病菌，但也发现这些病毒颗粒会影响哺乳动物的免疫系统。IBD是一种病因不明的慢性多因素炎症。本综述重点介绍当前的研究，表明了噬菌体与哺乳动物免疫细胞的相互作用可以影响疾病进程，而不仅仅是已知的感染细菌的作用，据此可能会确定治疗或诊断IBD的新方法。
外文摘要：Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are influenced by the bacterial and fungal organisms found within the intestine. However, the intestine is also home to a vast number of viral particles, with most of them being viruses that infect prokaryotes, called bacteriophages. While use of bacteriophages to specifically target pathogenic bacterial species involved in IBD is currently under investigation, recent studies have also highlighted that these viral particles can impact the mammalian immune system. IBD is a chronic multi-factorial inflammatory condition with unknown etiology. This review will highlight the current investigations that have revealed that bacteriophagemammalian immune cell interactions can influence disease processes beyond their known role for infecting bacteria, which might identify novel ways to treat or diagnose IBD.
作者：Gogokhia, L；Round, JL
作者单位：Univ Utah；St Marys Hosp
期刊名称：CURRENT OPINION IN VIROLOGY
期刊影响因子：4.985
出版年份：2021
出版刊次：49
点击下载：炎症性肠病中免疫-噬菌体的相互作用