中文摘要：几十年来，临床实践中一直用抗生素作为治疗细菌相关感染的正统药物。然而，抗生素的过度使用导致了抗菌素耐药性(AMR)或多药耐药性物种的激增。细菌也可以生长到生物膜中，生物膜至少占感染的三分之二。独特的基因表达和自产异构水合胞外聚合物生物膜基质结构有助于细菌耐受性，并表现为抗生素耐药性。本文介绍了对抗生物膜形成和AMR的困难，并讨论了从化合物到水凝胶，从无机到生物的新型抗生素替代品，如金属纳米颗粒和季铵盐化合物、壳聚糖及其衍生物、抗菌肽、刺激反应材料、噬菌体治疗及其他治疗策略，为寻求AMR和生物膜相关感染问题解决方案的读者提供有用的信息。
外文摘要：Antibiotics have been denoted as the orthodox therapeutic agents for fighting bacteria-related infections in clinical practices for decades. Nevertheless, overuse of antibiotics has led to the upsurge of species with antimicrobial resistance (AMR) or multi-drug resistance. Bacteria can also grow into the biofilm, which accounts for at least two-thirds of infections. Distinct gene expression and self-produced heterogeneous hydrated extracellular polymeric substance matrix architecture of biofilm contribute to their tolerance and externally manifest as antibiotic resistance. In this review, the difficulties in combating biofilm formation and AMR are introduced, and novel alternatives to antibiotics such as metal nanoparticles and quaternary ammonium compounds, chitosan and its derivatives, antimicrobial peptides, stimuli-responsive materials, phage therapy and other therapeutic strategies, from compounds to hydrogel, from inorganic to biological, are discussed. We expect to provide useful information for the readers who are seeking for solutions to the problem of AMR and biofilm-related infections.
外文关键词：Bacteria；Biofilm；Antibiotics；AMR；Infection；Therapeutic strategies
作者：Xu, Q；Hu, XF；Wang, YB
作者单位：Sichuan Univ
期刊名称：MOLECULAR BIOTECHNOLOGY
期刊影响因子：2.022
出版年份：2021
出版刊次：
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