中文摘要：用于面部防护设备的透明材料可防止病毒和细菌，包括多重耐药菌株引起的微生物感染。然而，此类透明材料由不具有抗菌活性的材料制成。它们只能避免人与生物制剂之间的直接接触。因此，健康人可能通过接触受污染的材料表面而受到感染，该设备反而成为了越来越多的传染性生物废物来源。而且受感染者很容易传播微生物感染，因为防护设备不会使呼吸、打喷嚏或咳嗽时产生的微生物失活。本研究旨在制造一种具有内在抗菌活性的透明面罩，它可以提供额外的保护，防止感染性病原体，减少感染性废物的产生。因此，开发了由聚对苯二甲酸乙二醇酯和苯扎氯铵抗菌涂层组成的一次性透明抗菌面罩，用作下一代面部防护设备。用原子力显微镜和场发射扫描电镜对抗菌涂层进行了元素分析。这是第一种面部透明保护材料，能够在不到一分钟的接触时间内灭活包膜病毒，如严重急性呼吸综合征冠状病毒2（SARS-CoV-2），以及耐甲氧西林金黄色葡萄球菌和表皮葡萄球菌。细菌感染导致SARS-CoV-2感染相关的严重肺炎，并且他们对抗生素的耐药性越来越强。我们的超防护广谱抗菌复合材料还可用于制造其他面部防护工具，如护目镜、头盔、塑料面罩和柜台或车辆用空间隔离屏。该技术成本低，对发达国家和欠发达国家防治当前流行病，保护卫生保健工作者免受多重耐药性感染非常有用。
外文摘要：Transparent materials used for facial protection equipment provide protection against microbial infections caused by viruses and bacteria, including multidrug-resistant strains. However, transparent materials used for this type of application are made of materials that do not possess antimicrobial activity. They just avoid direct contact between the person and the biological agent. Therefore, healthy people can become infected through contact of the contaminated material surfaces and this equipment constitute an increasing source of infectious biological waste. Furthermore, infected people can transmit microbial infections easily because the protective equipment do not inactivate the microbial load generated while breathing, sneezing or coughing. In this regard, the goal of this work consisted of fabricating a transparent face shield with intrinsic antimicrobial activity that could provide extra-protection against infectious agents and reduce the generation of infectious waste. Thus, a single-use transparent antimicrobial face shield composed of polyethylene terephthalate and an antimicrobial coating of benzalkonium chloride has been developed for the next generation of facial protective equipment. The antimicrobial coating was analyzed by atomic force microscopy and field emission scanning electron microscopy with elemental analysis. This is the first facial transparent protective material capable of inactivating enveloped viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in less than one minute of contact, and the methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Bacterial infections contribute to severe pneumonia associated with the SARS-CoV-2 infection, and their resistance to antibiotics is increasing. Our extra protective broad-spectrum antimicrobial composite material could also be applied for the fabrication of other facial protective tools such as such as goggles, helmets, plastic masks and space separation screens used for counters or vehicles. This low-cost technology would be very useful to combat the current pandemic and protect health care workers from multidrug-resistant infections in developed and underdeveloped countries.
外文关键词：face shield；facial protective equipment；SARS-CoV-2；phage phi 6；MRSA；MRSE；polyethylene terephthalate；benzalkonium chloride；COVID-19；multidrug-resistant bacteria
作者：Tunon-Molina, A；Marti, M；Muramoto, Y；Noda, T；Takayama, K；Serrano-Aroca, A
作者单位：Univ Catolica Valencia San Vicente Martir；Kyoto Univ
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
期刊影响因子：4.556
出版年份：2021
出版刊次：17
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