中文摘要：感染嗜热链球菌的噬菌体是乳制品发酵工业，特别是嗜热生产系统中的一个主要问题。为此开展了许多与全球奶业中这种噬菌体生物多样性相关的研究。本文综述了这些噬菌体的遗传和形态多样性，并通过对代表性噬菌体复制和形态发生模块的比较蛋白质组学分析，强调了感染该物种的噬菌体间遗传嵌合的来源和程度。对所选噬菌体编码受体结合蛋白（RBPs）的系统发育进行了评估，表明在某些情况下，在形态发生模块中分别获得了RBP编码基因，从而突出了这些噬菌体的适应性。本综述进一步强调了在定义这些噬菌体的突发性遗传多样性组方面所取得的重大进展，同时也总结了该研究领域尚存的知识差距。
外文摘要：Streptococcus thermophilus-infecting phages represent a major problem in the dairy fermentation industry, particularly in relation to thermophilic production systems. Consequently, numerous studies have been performed relating to the biodiversity of such phages in global dairy operations. In the current review, we provide an overview of the genetic and morphological diversity of these phages and highlight the source and extent of genetic mosaicism among phages infecting this species through comparative proteome analysis of the replication and morphogenesis modules of representative phages. The phylogeny of selected phage-encoded receptor binding proteins (RBPs) was assessed, indicating that in certain cases RBP-encoding genes have been acquired separately to the morphogenesis modules, thus highlighting the adaptability of these phages. This review further highlights the significant advances that have been made in defining emergent genetically diverse groups of these phages, while it additionally summarizes remaining knowledge gaps in this research area.
外文关键词：replication；structure；phylogenetic；fermentations；cheese；food microbiology；lactic acid bacteria；phage-host interactions；recombination；modular exchange
作者：Hanemaaijer, L；Kelleher, P；Neve, H；Franz, C；de Waal, P；van Peij, N；van Sinderen, D；Mahony, J
作者单位：DSM Biotechnol Ctr；Univ Coll Cork；Max Rubner Inst
期刊名称：MICROORGANISMS
期刊影响因子：4.152
出版年份：2021
出版刊次：9
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