中文摘要：本研究评估了壳聚糖包裹噬菌体混合物作为智能生物防治剂的治疗效果，用作胃肠道感染的预防和治疗。以肠沙门菌、福氏志贺氏菌、大肠杆菌感染大鼠作为实验对象，评价了噬菌体制剂对胃肠道感染的治疗作用。给大鼠称重并培养其粪便，结果表明，壳聚糖包裹的噬菌体混合物组在3天后体重没有减轻，组体重变化显著降低。服用头孢克肟的大鼠体重明显减轻；并且与壳聚糖包裹的噬菌体混合物治疗组的2天相比，4天后阳性培养粪便减少。可见，壳聚糖包裹的噬菌体混合物可有效治疗胃肠道感染。
外文摘要：The therapeutic effectiveness of a chitosan encapsulated bacteriophage cocktail as a smart biocontrol agent was evaluated in this study to be used as a preventative and treatment option for gastrointestinal infections. To evaluate the effect of the bacteriophage formulation on the treatment of gastrointestinal infection, rats were infected with Salmonella enterica, Shigella flexneri, and Escherichia coli. The rats were weighed and their stools cultured. The results showed that the group which had the chitosan encapsulated bacteriophage cocktail did not lose weight after 3 days and had significantly lower group weight changes. Weight loss was significant in the rats that had cefixime administered instead. Positive cultured stools were reduced after 4 days compared to 2 days in the treated group with the chitosan encapsulated bacteriophage cocktail. The chitosan encapsulated bacteriophage cocktail can therefore be effective in the treatment of gastrointestinal infections.
外文关键词：HEMOLYTIC-UREMIC SYNDROME；LYTIC ACTIVITY；IN-VITRO；PHAGES；NANOPARTICLES；NANOMATERIALS
作者：Rahimzadeh, G；Saeedi, M；Moosazadeh, M；Hashemi, SMH；Babaei, A；Rezai, MS；Kamel, K；Asare-Addo, K；Nokhodchi, A
作者单位：Mazandaran Univ Med Sci；Sari Agr Sci & Nat Resources Univ；Univ Huddersfield；Univ Sussex
期刊名称：SCIENTIFIC REPORTS
期刊影响因子：3.998
出版年份：2021
出版刊次：1
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