中文摘要：抗生素耐药菌是全球人类和动物健康的主要威胁之一。耐药菌中最有害的是产8-内酰胺酶的革兰氏阴性菌。8-内酰胺酶构成了抗生素耐药性进化的范式转变。因此，有必要对产生耐药性的机制进行全面综述。由8-内酰胺酶产生的耐药性通过多种机制发展，并且涉及到可通过质粒在细菌之间转移的耐药基因的数量。随着时间的推移，逐渐揭示了这些新的基于分子的抗性机制。本文综述了革兰氏阴性菌对8-内酰胺类抗生素耐药的分子机制的最新信息，包括具有甲基化酶活性的CTX-M型ESBLs，含有8-内酰胺耐药基因的噬菌体的质粒，独特组合的8-内酰胺耐药基因的共同存在以及同一细菌中8-内酰胺和非8-内酰胺抗生素耐药基因的共同存在。因此，从分子水平上研究8-内酰胺抗性的发展，可采取多因素协调措施应对8-内酰胺耐药性快速增长的挑战。
外文摘要：Antibiotic-resistant bacteria are considered one of the major global threats to human and animal health. The most harmful among the resistant bacteria are 8-lactamase producing Gram-negative species (8-lactamases). 8-lactamases constitute a paradigm shift in the evolution of antibiotic resistance. Therefore, it is imperative to present a comprehensive review of the mechanisms responsible for developing antimicrobial resistance. Resistance due to 8-lactamases develops through a variety of mechanisms, and the number of resistant genes are involved that can be transferred between bacteria, mostly via plasmids. Over time, these new molecular-based resistance mechanisms have been progressively disclosed. The present review article provides information on the recent findings regarding the molecular mechanisms of resistance to 8-lactams in Gram-negative bacteria, including CTX-M-type ESBLs with methylase activity, plasmids harbouring phages with 8-lactam resistance genes, the co-presence of 8-lactam resistant genes of unique combinations and the presence of 8-lactam and non8-lactam antibiotic-resistant genes in the same bacteria. Keeping in view, the molecular level resistance development, multifactorial and coordinated measures may be taken to counter the challenge of rapidly increasing 8-lactam resistance.
外文关键词：Antibiotic resistance；Gram negative bacteria；8-lactamase；Molecular mechanisms；Public Health
作者：Hussain, HI；Aqib, AI；Seleem, MN；Shabbir, MA；Hao, HH；Iqbal, Z；Kulyar, MFEA；Zaheer, T；Li, K
作者单位：Cholistan Univ Vet & Anim Sci；Purdue Univ；Univ Vet & Anim Sci；Huazhong Agr Univ；Shenzhen Univ；Univ Agr Faisalabad；Nanjing Agr Univ
期刊名称：MICROBIAL PATHOGENESIS
期刊影响因子：2.914
出版年份：2021
出版刊次：158
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