中文摘要：耐粘菌素的多药耐药（MDR）、广泛耐药（XDR）和泛耐药（PDR）细菌具有高度致死性，世界各地的研究人员都在致力于对付这些微生物。由这些细菌引起的感染对抗生素治疗这一最终手段产生耐药性，对临床和公共卫生构成重大挑战。由于新抗生素的生产非常昂贵，而与抗生素耐药性的增加速度相比又相当缓慢，研究人员建议使用具有高抗菌潜力的天然物质。噬菌体是目前治疗不治之症和高度耐药感染最有效的治疗措施之一。噬菌体无副作用、能扩散到身体各器官、与抗生素的作用方式不同以及可在感染部位增殖而受到高度重视。虽然噬菌体对MDR和XDR细菌的作用已在各种研究中得到证实，但只有少数研究表明噬菌体治疗对耐粘菌素菌株有用。因此，本综述讨论了临床上由耐粘菌素的MDR和XDR细菌引起的问题，解释了与粘菌素耐药性相关的不同机制，介绍了噬菌体疗法作为一种有效的治疗方法，最后介绍了使用噬菌体对抗耐粘菌素菌株的新研究。
外文摘要：Colistin-resistant multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria are highly lethal and many researchers have tried hard to combat these microorganisms around the world. Infections caused by these bacteria are resistant to the last resort of antibiotic therapy and have posed a major challenge in clinical and public health. Since the production of new antibiotics is very expensive and also very slow compared to the increasing rate of antibiotic resistance, researchers are suggesting the use of natural substances with high antibacterial potential. Bacteriophages are one of the most effective therapeutic measures that are known to exist for use for incurable and highly resistant infections. Phages are highly taken into consideration due to the lack of side effects, potential spread to various body organs, distinct modes of action from antibiotics, and proliferation at the site of infection. Although the effects of phages on MDR and XDR bacteria have been demonstrated in various studies, only a few have investigated the effect of phage therapy on colistin-resistant isolates. Therefore, in this review, we discuss the problems caused by colistin-resistant MDR and XDR bacteria in the clinics, explain the different mechanisms associated with colistin resistance, introduce bacteriophage therapy as a powerful remedy, and finally present new studies that have used bacteriophages against colistin-resistant isolates.
外文关键词：ESCHERICHIA-COLI；WOUND-INFECTION；ACINETOBACTER；MECHANISMS；PREVALENCE；EFFICACY；GENES；LIPOPOLYSACCHARIDE；ART-175；CELLS
作者：Mousavi, SM；Babakhani, S；Moradi, L；Karami, S；Shahbandeh, M；Mirshekar, M；Mohebi, S；Moghadam, MT
作者单位：Iran Univ Med Sci；Islamic Azad Univ；Ahvaz Jundishapur Univ Med Sci；Shiraz Univ Med Sci
期刊名称：CURRENT MICROBIOLOGY
期刊影响因子：1.746
出版年份：2021
出版刊次：
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