中文摘要：全球出现的耐多药病原体正在形成目前关于使用抗生素治疗的规范。许多细菌已经进化出对传统的抗生素疗法产生耐药性，给患者带来了健康和经济负担。探索替代和补充治疗方法加强并恢复了噬菌体治疗；而近几十年来，噬菌体基因组编码的细胞裂解酶的外源性使用效果令人鼓舞。这两种抗菌剂能减少细菌数量；但许多障碍会阻碍它们在感染部位迅速递送。将它们封装在运载工具中，通过受控的复合物递送，可使它们越过化学、物理和免疫屏障，提供靶向治疗。本文综述了噬菌体和细胞裂解酶在解决呼吸、消化和表皮系统细菌感染方面的应用现状，强调了二者在这三个系统中所面临的不同挑战，并讨论了在更广泛地使用运载工具方面取得的进展。
外文摘要：The global emergence of multidrug-resistant pathogens is shaping the current dogma regarding the use of antibiotherapy. Many bacteria have evolved to become resistant to conventional antibiotherapy, representing a health and economic burden for those afflicted. The search for alternative and complementary therapeutic approaches has intensified and revived phage therapy. In recent decades, the exogenous use of lysins, encoded in phage genomes, has shown encouraging effectiveness. These two antimicrobial agents reduce bacterial populations; however, many barriers challenge their prompt delivery at the infection site. Encapsulation in delivery vehicles provides targeted therapy with a controlled compound delivery, surpassing chemical, physical and immunological barriers that can inactivate and eliminate them. This review explores phages and lysins' current use to resolve bacterial infections in the respiratory, digestive and integumentary systems. We also highlight the different challenges they face in each of the three systems and discuss the advances towards a more expansive use of delivery vehicles.
外文关键词：bacteriophages；lysins；encapsulation；clinical pathogens；infections；delivery
作者：Pinto, AM；Silva, MD；Pastrana, LM；Banobre-Lopez, M；Sillankorva, S
作者单位：LIBRO Lab Invest Biofilmes Rosario Oliveira
期刊名称：FEMS MICROBIOLOGY REVIEWS
期刊影响因子：13.92
出版年份：2021
出版刊次：5
点击下载：胶囊化噬菌体和细胞裂解酶的临床递送途径