中文摘要：群体感应（QS）在自然和合成微生物系统中都起着重要作用。QS的复杂性包括多层控制、生物分子串扰和基于种群的相互作用。本综述将复杂的基于QS的相互作用分为垂直和水平两个方面。对于前者，讨论了自然微生物系统中噬菌体、细菌和宿主之间基于QS信号和激素的相互作用；对于后者，强调了多组分合成微生物菌群基于QS相互作用的操作；并进一步介绍了在自然和合成微生物群中操纵这些相互作用（统称为“QS通信网络”）的最新和新兴应用，最终确定了为各种未来应用设计不同QS通信网络的关键挑战。
外文摘要：Quorum sensing (QS) plays an important role in both natural and synthetic microbial systems. The complexity of QS entails multilayer controls, biomolecular crosstalk, and population-based interactions. In this review, we divide complex QS-based interactions into vertical and horizontal interactions. With respect to the former, we discuss QS-based interactions among phages, bacteria, and hosts in natural microbial systems, which are based on various QS signals and hormones. With regard to the latter, we highlight manipulations of QS-based interactions for multicomponent synthetic microbial consortia. We further present the recent and emerging applications of manipulating these interactions (collectively referred to as 'QS communication networks') in natural and synthetic microbiota. Finally, we identify key challenges in engineering diverse QS communication networks for various future applications.
外文关键词：CELL-CELL COMMUNICATION；BACTERIA；INDOLE；SIGNAL；MICROBIOTA；HOST；BIOSYNTHESIS；EXPRESSION；FAMILY；SENSOR
作者：Wu, SB；Xu, CY；Liu, JH；Liu, CJ；Qiao, JJ
作者单位：Tianjin Univ；Collaborat Innovat Ctr Chem Sci & Engn Tianjin
期刊名称：TRENDS IN MICROBIOLOGY
期刊影响因子：13.546
出版年份：2021
出版刊次：12
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