中文摘要：本研究开发了一种简便、环保的方法来合成一种有效的抗菌剂，可有效对抗真菌、细菌和病毒。经FDA批准的生物相容性聚合物聚乙二醇（PEG）经抗坏血酸修饰，形成荧光聚乙二醇-抗坏血酸复合物（FL-PEG-AA）。随着抗坏血酸(AA)浓度的变化，荧光在可见范围内由绿变红。采用密度泛函理论(DFT)和时变密度泛函理论(DT-DFT)对抗坏血酸-单甘醇和抗坏血酸-六甘醇进行了研究，了解FL-PEG-AA体系的电子和成键性质。FL-PEG-AA的发射可归因于通过强氢键相互作用形成FL-PEG-AA的集成核。FL-PEG-AA的荧光已成功应用于了解乳腺癌细胞对其的摄取。在对真菌（白色念珠菌）、细菌：革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌）以及病毒（λ噬菌体）的测试中，FL-PEG-AA复合物显示出显著的生长抑制作用。FL-PEG-AA系统的抗菌活性证实该新型制剂可以作为强效抗菌剂。由于其具有粘性物理性质，FL-PEG-AA复合物可用作涂层剂或气溶胶喷涂剂。
外文摘要：In this report, a facile and eco-friendly method was developed to synthesize a potent antimicrobial agent, effective against fungus, bacteria, and virus. The biocompatible FDA approved polymer, polyethylene glycol (PEG), has been modified by ascorbic acid to form fluorescent polyethylene glycol-ascorbic acid complex (FL PEG AA). The flourescence of FL PEG AA complex could be tuned from green to red in the visible range with varying ascorbic acid(AA) concentrations. The Density Functional Theory (DFT) and the Time-Dependent Density Functional Theory (DT-DFT) on ascorbic acid-monoethylene glycol and ascorbic acid-hexaethylene glycol studies were performed to understand the electronic and bonding nature of FL PEG-ascorbic acid (FL PEG AA) system. The emission of FL PEG AA can be ascribed to the integrated core of FL PEG AA through strong hydrogenbonding interactions. The fluorescence of FL PEG AA was successfully applied to understand its cellular uptake by breast cancer cells. The FL PEG AA complex showed significant inhibition of growth, when tested against fungus (Candida albicans), bacteria: gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) and the virus (Bacteriophage lambda). The antimicrobial activity of the FL PEG AA system supports the application of this novel formulation as a potent antimicrobial agent. Due to its viscous physical nature, the FL PEG AA complex could be applied as a coating agent or aerosol spray.
外文关键词：Polyethylene glycol (PEG)；fluorescent polyethylene glycol (FL PEG)；DFT calculations；Antimicrobial properties；Bioimaging
作者：Appidi, T；Ravichandran, G；Mudigunda, SV；Thomas, A；Jogdand, AB；Kishen, S；Subramaniyam, K；Emani, N；Prabusankar, G；Rengan, AK
作者单位：Indian Inst Technol Hyderabad
期刊名称：MATERIALS TODAY COMMUNICATIONS
期刊影响因子：2.678
出版年份：2021
出版刊次：
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