中文摘要：COVID-19大流行凸显了开发抗病毒活性表面和涂层的重要性。本研究首次展示了能杀灭病毒的肽基组装体。组装体的最小抑菌浓度（MIC）为每毫升数十微克，比金属纳米粒子的MIC低了2个数量级。应用于表面时，通过滴注，球形肽组装体粘附在表面，形成抗病毒涂层，以对抗包括冠状病毒在内的RNA和DNA病毒。研究表明，与未经处理的表面相比，该涂层使T4噬菌体（DNA病毒）的数量减少了3 log，与原液相比减少了6 log。重要的是，这种涂层完全灭活了犬冠状病毒（RNA病毒）。该肽涂层可用于任何需要无菌表面以降低病毒传播风险的地方。
外文摘要：The COVID-19 pandemic highlighted the importance of developing surfaces and coatings with antiviral activity. Here, we present, for the first time, peptide-based assemblies that can kill viruses. The minimal inhibitory concentration (MIC) of the assemblies is in the range tens of micrograms per milliliter. This value is 2 orders of magnitude smaller than the MIC of metal nanoparticles. When applied on a surface, by drop casting, the peptide spherical assemblies adhere to the surface and form an antiviral coating against both RNA- and DNA-based viruses including coronavirus. Our results show that the coating reduced the number of T4 bacteriophages (DNA-based virus) by 3 log, compared with an untreated surface and 6 log, when compared with a stock solution. Importantly, we showed that this coating completely inactivated canine coronavirus (RNA-based virus). This peptide-based coating can be useful wherever sterile surfaces are needed to reduce the risk of viral transmission.
外文关键词：antiviral coatings；self-assembly；peptides；coronavirus；bacteriophage T4
作者：Hu, T；Agazani, O；Nir, S；Cohen, M；Pan, SY；Reches, M
作者单位：Hebrew Univ Jerusalem；Huazhong Agr Univ
期刊名称：ACS APPLIED MATERIALS & INTERFACES
期刊影响因子：8.758
出版年份：2021
出版刊次：41
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