中文摘要：有些植物和动物病原体可以操控它们的寄主，使它们释放对病原体节肢动物介体具有吸引力的气味。然而，这个过程中潜在的分子机制很大程度上还未有研究，病原体采用的特异效应物以及它们靶向寄主的途径仍是未知之谜。本研究发现，蚜虫传播的黄瓜花叶病毒（CMV）利用其2b蛋白，以寄主茉莉酸（JA）途径为靶标，从而充当寄主对昆虫介体吸引力的诱导者。
外文摘要：Some plant and animal pathogens can manipulate their hosts to cause them to release odors that are attractive to the pathogens' arthropod vectors. However, the molecular mechanism underlying this process is largely unexplored, and the specific effectors the pathogens employ as well as the pathways within the hosts they target are currently unknown. Here we reveal that the aphid-borne cucumber mosaic virus (CMV) employs its 2b protein, a well-characterized viral suppressor of host RNA interference (VSR), to target the host's jasmonate (JA) hormone pathway, thus acting as a viral inducer of host attractiveness to insect vectors (VIA). 2b inhibits JA signaling by directly interacting with and repressing JA-induced degradation of host jasmonate ZIM-domain proteins, instead of using its VSR activity. Our findings identify a previously defined VSR protein as a VIA and uncover a molecular mechanism CMV uses to manipulate host's attractiveness to insect vectors by targeting host hormone signaling.
外文关键词：cucumber mosaic virus; jasmonate; VSR; VIA; 2b
作者：Wu, Dewei; Qi, Tiancong; Li, Wan-Xiang; 等
作者单位：清华大学
期刊名称：清华大学
期刊影响因子：14.812
出版年份：2017
出版刊次：3
点击下载：病毒效应蛋白操控寄主激素信号以吸引昆虫介体