中文摘要：番茄黄化曲叶病毒（TYLCV）是一种双生病毒，可引起被侵染的番茄及其介体烟粉虱中蛋白质聚集。TYLCV与植物中HSP70和HSP90的交互作用对病毒侵染的进行是很有必要的。在感染病毒的寄主细胞中，HSP70和HSP90从可溶性到聚合状态重新分配。TYLCV CP可与HSPs在番茄和烟粉虱中构成复合物。但是，HSP70和HSP90在寄主植物病毒细胞周期中发挥着不同的作用。本研究结果表明，烟粉虱获取病毒的效率取决于植物伴侣蛋白的功能以及它们与其他蛋白机制（能控制病毒诱导聚集体的）之间的交叉。
外文摘要：Tomato yellow leaf curl virus (TYLCV), a begomovirus, induces protein aggregation in infected tomatoes and in its whitefly vector Bemisia tabaci. The interactions between TYLCV and HSP70 and HSP90 in plants and vectors are necessity for virus infection to proceed. In infected host cells, HSP70 and HSP90 are redistributed from a soluble to an aggregated state. These aggregates contain, together with viral DNA/proteins and virions, HSPs and components of the protein quality control system such as ubiquitin, 26S proteasome subunits, and the autophagy protein ATG8. TYLCV CP can form complexes with HSPs in tomato and whitefly. Nonetheless, HSP70 and HSP90 play different roles in the viral cell cycle in the plant host. In the infected host cell, HSP70, but not HSP90, participates in the translocation of CP from the cytoplasm into the nucleus. Viral amounts decrease when HSP70 is inhibited, but increase when HSP90 is downregulated. In the whitefly vector, HSP70 impairs the circulative transmission of TYLCV; its inhibition increases transmission. Hence, the efficiency of virus acquisition by whiteflies depends on the functionality of both plant chaperones and their cross-talk with other protein mechanisms controlling virus-induced aggregation.
外文关键词：begomovirus; heat shock proteins; protein quality control; tomato; whitefly
作者：Gorovits, Rena; Czosnek, Henryk
作者单位：以色列希伯莱大学
期刊名称：FRONTIERS IN PLANT SCIENCE
期刊影响因子：4.495
出版年份：2017
出版刊次：3
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