中文摘要：没有证据表明昆虫传播的病毒是否操纵昆虫介体c-Jun N端激酶（JNK）信号通路。本文利用植物病毒水稻条纹病毒（RSV）与其介体昆虫灰飞虱组成的系统来研究介体昆虫JNK通路对植物病毒侵染的反应。研究发现，RSV增加了昆虫体内肿瘤坏死因子-α水平，降低了G蛋白通路抑制基因2（GPS2）水平。研究证实，JNK活性促进了昆虫体内RSV的复制，然而JNK的抑制性导致了病毒的显著减少并因此影响了植物发病率。这些结果表明，昆虫介体JNK的抑制可能是控制植物病毒传播的有效策略。
外文摘要：No evidence has shown whether insect-borne viruses manipulate the c-Jun N-terminal kinase (JNK) signaling pathway of vector insects. Using a system comprising the plant virus Rice stripe virus (RSV) and its vector insect, the small brown planthopper, we have studied the response of the vector insect’s JNK pathway to plant virus infection. We found that RSV increased the level of Tumor Necrosis Factor-α and decreased the level of G protein Pathway Suppressor 2 (GPS2) in the insect vector. The virus capsid protein competitively bound GPS2 to release it from inhibiting the JNK activation machinery. We confirmed that JNK activation promoted RSV replication in the vector, whereas JNK inhibition caused a significant reduction in virus production and thus delayed the disease incidence of plants. These findings suggest that inhibition of insect vector JNK may be a useful strategy for controling the transmission of plant viruses.
作者：Wang, Wei; Zhao, Wan; Li, Jing; 等
作者单位：中国科学院
期刊名称：ELIFE
期刊影响因子：5.41
出版年份：2017
出版刊次：7
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