中文摘要：RNA沉默（或RNA干扰、RNAi）在植物抗病毒防御中起着关键的作用。为了便于侵染，病毒编码RNA沉默抑制子（VSRs）以抵消抗病毒防御。本文总结并探讨了抗病毒RNAi防御和VSRs的多重功能，揭示了VSRs在寄主与病毒间动态地集成连接中起着中枢调节的作用。
外文摘要：RNA silencing (or RNA interference, RNAi) plays a key role in the plant antiviral defense. To facilitate infection, viruses encode suppressors of RNA silencing (VSRs) to counteract antiviral defense. In the co-evolutionary arms race between hosts and viruses, extreme viral accumulation does not benefit either hosts or viruses. During viral infection, antiviral silencing and VSRs have dual effects to maintain the balance between plant development and virus accumulation. Here, we summarize and discuss the multiple functions of the antiviral RNAi defense and VSRs, revealing the central hub regulators of VSRs in dynamically integrated connections between hosts and viruses.
作者：Zhao, Jian-Hua；Hua, Chen-Lei；Fang, Yuan-Yuan；等
作者单位：中国科学院微生物研究所
期刊名称：CURRENT OPINION IN VIROLOGY
期刊影响因子：5.313
出版年份：2016
出版刊次：4
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